(2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion

Base Information

Chemical Name:(2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion
CAS No.:84133-18-6
Molecular Formula:C₃₃H₄₆N₄O₇
Molecular Weight:610.751
Hs Code.:

(2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion

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Chemical Property of (2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion

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Technology Process of (2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion

There total 19 articles about (2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 84133-17-5
(S)-2-{(2S,3S)-2-[3-[5-(2-Benzyloxycarbonylamino-1-hydroxy-ethyl)-2-methoxy-phenyl]-2-(tert-butoxycarbonyl-methyl-amino)-propionylamino]-3-methyl-pentanoylamino}-3-phenyl-propionic acid pentafluorophenyl ester

: 84133-18-6,91465-38-2,91465-39-3
[(6S,9S)-6-Benzyl-9-((S)-sec-butyl)-2-hydroxy-15-methoxy-5,8,11-trioxo-4,7,10-triaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-trien-12-yl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium; In 1,4-dioxane; at 95 ℃; for 5h;

Reference yield: 85.0%

: 84133-17-5,91465-36-0,91465-37-1
<(2S)-5'-<(1RS)-2-(Benzyloxycarbonylamino)-1-hydroxyethyl>-N-(tert-butyloxycarbonyl)-2'-methoxy-N-methylphenylalanyl>-(S)-isoleucyl-(S)-phenylalanin-pentafluorphenylester

: 84133-18-6,91465-38-2,91465-39-3
(2RS,6S,9S,12S)-12-<(tert-Butyloxycarbonyl)(methyl)amino>-2-hydroxy-15-methoxy-9-(1-methylpropyl)-6-phenylmethyl-4,7,10-triazabicyclo<12.3.1>octadeca-1(18),14,16-trien-5,8,11-trion

Guidance literature:: With hydrogen; 4-pyrrolidin-1-ylpyridine; palladium on activated charcoal; In 1,4-dioxane; ethanol; at 95 ℃; for 5h;
DOI:10.1002/jlac.198419840616

Reference yield:

: 54793-60-1
H-(S)-Ile-(S)-Phe-OCH₃

: 84133-18-6,91465-38-2,91465-39-3
[(6S,9S)-6-Benzyl-9-((S)-sec-butyl)-2-hydroxy-15-methoxy-5,8,11-trioxo-4,7,10-triaza-bicyclo[12.3.1]octadeca-1⁽¹⁸⁾,14,16-trien-12-yl]-methyl-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1) NaOH, 2) DCCD / 1) H₂O/dioxane, r.t., 4h, 2) CH₂Cl₂, 0 deg C, 10h

2: NaOH / H₂O; dioxane / 4 h / Ambient temperature

3: DCCD / CH₂Cl₂ / 10 h / 0 °C

4: 85 percent / H₂ / Pd / dioxane / 5 h / 95 °C

With sodium hydroxide; hydrogen; dicyclohexyl-carbodiimide; palladium; In 1,4-dioxane; dichloromethane; water;