Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester

Base Information

• Chemical Name: Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester
• CAS No.: 864712-71-0
• Molecular Formula: C₅₁H₇₂O₁₀SSi₂
• Molecular Weight: 933.364

Synonyms:

Chemical Property of Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester

There total 6 articles about Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R,4R)-2,3-bis(benzyloxy)-10-t-butyldiphenylsiloxy-4-triethylsiloxy-4-methyldecanal (864712-67-4) → Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester (864712-71-0)

Guidance literature:

Multi-step reaction with 5 steps

1: benzene

2: OsO₄; aq. NMO / acetone

3: LiBH₄ / tetrahydrofuran

4: (Im)2 / benzene

5: DMAP; pyridine

With pyridine; dmap; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; In tetrahydrofuran; acetone; benzene; 1: Wittig reaction;

DOI:10.1016/j.tetlet.2005.06.079

Reference yield:

(2S,3R,4R)-2,3-Bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-4-triethylsilanyloxy-decan-1-ol → Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester (864712-71-0)

Guidance literature:

Multi-step reaction with 6 steps

1: (COCl)2; DMSO; Et₃N / CH₂Cl₂

2: benzene

3: OsO₄; aq. NMO / acetone

4: LiBH₄ / tetrahydrofuran

5: (Im)2 / benzene

6: DMAP; pyridine

With pyridine; dmap; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; oxalyl dichloride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; dichloromethane; acetone; benzene; 1: Swern oxidation / 2: Wittig reaction;

DOI:10.1016/j.tetlet.2005.06.079

Reference yield:

(E,4S,5R,6R)-methyl 4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-6-methyldodec-2-enoate (887768-95-8) → Methanesulfonic acid (1S,2R,3R,4R)-2,3-bis-benzyloxy-10-(tert-butyl-diphenyl-silanyloxy)-4-methyl-1-((R)-2-oxo-[1,3]dioxolan-4-yl)-4-triethylsilanyloxy-decyl ester (864712-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1: OsO₄; aq. NMO / acetone

2: LiBH₄ / tetrahydrofuran

3: (Im)2 / benzene

4: DMAP; pyridine

With pyridine; dmap; osmium(VIII) oxide; lithium borohydride; N-methyl-2-indolinone; In tetrahydrofuran; acetone; benzene;

DOI:10.1016/j.tetlet.2005.06.079

upstream raw materials:

(R)-4-[(1S,2S,3R,4R)-2,3-bis(benzyloxy)-10-t-butyldiphenylsiloxy-4-triethylsiloxy-1-hydroxy-4-methyldecyl]-1,3-dioxolan-2-one

methanesulfonyl chloride

(2R,3R,4R)-2,3-bis(benzyloxy)-10-t-butyldiphenylsiloxy-4-triethylsiloxy-4-methyldecanal

(E,4S,5R,6R)-methyl 4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-6-methyldodec-2-enoate

Downstream raw materials:

(2S,3R,4S,5R,6R)-4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-2,6-dimethyldodecane-1,3-diol

(2R,3R,4S,5R,6R)-4,5-Bis-benzyloxy-12-(tert-butyl-diphenyl-silanyloxy)-3-(4-methoxy-benzyloxy)-2,6-dimethyl-6-triethylsilanyloxy-dodecanal

(2S,3R,4S,5R,6R)-4,5-bis(benzyloxy)-12-t-butyldiphenylsiloxy-6-triethylsiloxy-3-(4-methoxybenzyloxy)-2,6-dimethyldodeca-1-ol

(E)-3-{(2R,3R)-3-[(1R,2R,3S,4R,5R)-3,4-Bis-benzyloxy-11-(tert-butyl-diphenyl-silanyloxy)-2-hydroxy-1,5-dimethyl-5-triethylsilanyloxy-undecyl]-2-methyl-oxiranyl}-acrylic acid methyl ester

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