isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester

Base Information

• Chemical Name: isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester
• CAS No.: 867278-06-6
• Molecular Formula: C₅₃H₅₆N₇O₁₄PS
• Molecular Weight: 1078.11
• Mol file: 867278-06-6.mol

Synonyms:

Chemical Property of isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester

There total 1 articles about isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Isopropoxy-acetic acid (2R,3S,5R)-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester + 1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-((R)-2-thioxo-2λ5-[1,3,2]oxathiaphospholan-2-yloxy)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione → isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester (867278-06-6)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene;

DOI:10.1016/j.tetlet.2005.07.158

Reference yield:

isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester (867278-06-6) → thiophosphoric acid O-[5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester O'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester (130854-98-7)

Guidance literature:

With ammonium hydroxide; In 1,4-dioxane; at 20 ℃;

DOI:10.1016/j.tetlet.2005.07.158

Reference yield:

isopropoxy-acetic acid 5-(6-benzoylamino-purin-9-yl)-2-{[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yloxy]-mercapto-phosphoryloxymethyl}-tetrahydro-furan-3-yl ester (867278-06-6) → C55H53N8O14PS (867277-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. NH₃ / dioxane / 20 °C

2: triethylamine / acetonitrile / 24 h / 20 °C

With ammonium hydroxide; triethylamine; In 1,4-dioxane; acetonitrile;

DOI:10.1016/j.tetlet.2005.07.158

Downstream raw materials:

thiophosphoric acid O-[5-(6-benzoylamino-purin-9-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl] ester O'-[2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester

C₅₅H₅₃N₈O₁₄PS