Vildagliptin iMpurity K

Base Information

• Chemical Name: Vildagliptin iMpurity K
• CAS No.: 565453-39-6
• Molecular Formula: C₁₇H₂₇N₃O₃
• Molecular Weight: 321.42
• Mol file: 565453-39-6.mol

Synonyms:

Chemical Property of Vildagliptin iMpurity K

Chemical Property:

• Melting Point: 94-96 °C
• Boiling Point: 585.9±50.0 °C(Predicted)
• PKA: 15.05±0.40(Predicted)
• Density: 1.31±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: N-(3-Hydroxytricyclo[3.3.1.13,7]dec-1-yl)glycyl-L-prolinamide is an impurity of Vildagliptin (V305000) which is an oral anti-hyperglycemic agent that inhibit dipeptidyl peptidase 4 (DPP-4).

Technology Process of Vildagliptin iMpurity K

There total 12 articles about Vildagliptin iMpurity K which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid methyl ester → (S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide (565453-39-6)

Guidance literature:

With ammonia; In methanol; at 10 - 75 ℃;

Reference yield: 90.0%

vildagliptin (1044676-63-2) → vildagliptinamide (565453-39-6)

Guidance literature:

With potassium hydroxide; In water; acetonitrile; at 60 ℃; for 5h; Solvent; Temperature; Reagent/catalyst;

Reference yield: 65.0%

[(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid (1032564-18-3) + L-prolinamide (7531-52-4) → (S)-1-[2-(3-hydroxyadamantan-1-ylamino)acetyl]pyrrolidine-2-carboxylic acid amide (565453-39-6)

Guidance literature:

With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; In ethyl acetate; acetone;

upstream raw materials:

3-aminoadamantan-1-ol

(S)-1-(2-chloroacetyl) pyrrolidine-2-carboxamide

L-prolinamide

[(3‐hydroxytricyclo[3.3.1.13,7]decan‐1‐yl)amino]acetic acid