{3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester

Base Information

• Chemical Name: {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester
• CAS No.: 142230-55-5
• Molecular Formula: C₃₈H₄₈N₁₀O₉
• Molecular Weight: 788.861

Synonyms:

Chemical Property of {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester

Chemical Property:

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MSDS Files:

Useful:

Technology Process of {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester

There total 9 articles about {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N-(4-Amino-butyl)-4-nitro-benzamide; hydrochloride (142310-72-3) + 4-[(4-{[4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-pyrrole-2-carbonyl]-amino}-1-methyl-1H-pyrrole-2-carbonyl)-amino]-1-methyl-1H-pyrrole-2-carboxylic acid (142230-52-2) → {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester (142230-55-5)

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/S0040-4039(00)79060-5

Reference yield:

N-(tert-butoxycarbonyl)-4-aminobutanoic acid (57294-38-9) → {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester (142230-55-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide

4: 95 percent

5: 78 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide, HOBt

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/S0040-4039(00)79060-5

Reference yield:

4-<<<4-<<4-butyryl>amino>-1-methyl-2-pyrrolyl>carbonyl>amino>-1-methyl-2-pyrrolecarboxylic acid (123993-09-9) → {3-[1-Methyl-5-(1-methyl-5-{1-methyl-5-[4-(4-nitro-benzoylamino)-butylcarbamoyl]-1H-pyrrol-3-ylcarbamoyl}-1H-pyrrol-3-ylcarbamoyl)-1H-pyrrol-3-ylcarbamoyl]-propyl}-carbamic acid tert-butyl ester (142230-55-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide

2: 95 percent

3: 78 percent / 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide, HOBt

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide;

DOI:10.1016/S0040-4039(00)79060-5

upstream raw materials:

N-(4-Amino-butyl)-4-nitro-benzamide; hydrochloride

4-[(4-{[4-(4-tert-Butoxycarbonylamino-butyrylamino)-1-methyl-1H-pyrrole-2-carbonyl]-amino}-1-methyl-1H-pyrrole-2-carbonyl)-amino]-1-methyl-1H-pyrrole-2-carboxylic acid

N-(tert-butoxycarbonyl)-4-aminobutanoic acid

4-<<<4-<<4-butyryl>amino>-1-methyl-2-pyrrolyl>carbonyl>amino>-1-methyl-2-pyrrolecarboxylic acid

Downstream raw materials:

Distamycin-amine hydrochloride

C₄₆H₄₇N₁₁O₇*ClH

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