1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

Base Information

Chemical Name:1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol
CAS No.:75969-98-1
Molecular Formula:C₃₀H₃₄N₂O₅
Molecular Weight:502.61
Hs Code.:

Synonyms:

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Chemical Property of 1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

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Technology Process of 1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

There total 9 articles about 1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2606-51-1
3,4-Methylenedioxybenzyl bromide

: 75969-98-1
1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: LDA / -78 °C

2: one pot denitrosation

3: 74 percent / Et₃N / dioxane / 40 °C

4: 74 percent / NaOCl/Bu₄N(+)HSO₄(-) / CH₂Cl₂; ethyl acetate

5: 62 percent / tetrahydrofuran / -78 °C

6: H₂ / Raney-Ni / methanol

7: LAH / tetrahydrofuran

With sodium hypochlorite; lithium aluminium tetrahydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)93647-5

Reference yield:

: 23101-41-9
(+/-)dimethoxy-6,7 hydroxy-4 tetrahydro-1,2,3,4 isoquinoleine

: 75969-98-1
1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

Guidance literature:: Multi-step reaction with 8 steps

1: NaNO₂/CH₃COOH

2: LDA / -78 °C

3: one pot denitrosation

4: 74 percent / Et₃N / dioxane / 40 °C

5: 74 percent / NaOCl/Bu₄N(+)HSO₄(-) / CH₂Cl₂; ethyl acetate

6: 62 percent / tetrahydrofuran / -78 °C

7: H₂ / Raney-Ni / methanol

8: LAH / tetrahydrofuran

With sodium hypochlorite; lithium aluminium tetrahydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; acetic acid; triethylamine; lithium diisopropyl amide; sodium nitrite; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)93647-5

Reference yield:

: 75969-91-4
6,7-Dimethoxy-2-nitroso-1,2,3,4-tetrahydro-isoquinolin-4-ol

: 75969-98-1
1-Benzo[1,3]dioxol-5-ylmethyl-2-benzyl-6,7-dimethoxy-4-pyrrolidin-2-yl-1,2,3,4-tetrahydro-isoquinolin-4-ol

Guidance literature:: Multi-step reaction with 7 steps

1: LDA / -78 °C

2: one pot denitrosation

3: 74 percent / Et₃N / dioxane / 40 °C

4: 74 percent / NaOCl/Bu₄N(+)HSO₄(-) / CH₂Cl₂; ethyl acetate

5: 62 percent / tetrahydrofuran / -78 °C

6: H₂ / Raney-Ni / methanol

7: LAH / tetrahydrofuran

With sodium hypochlorite; lithium aluminium tetrahydride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; lithium diisopropyl amide; nickel; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/S0040-4039(00)93647-5