(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

Base Information

Chemical Name:(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid
CAS No.:1308379-42-1
Molecular Formula:C₃₄H₃₇F₇N₅O₆P
Molecular Weight:775.66
Hs Code.:

(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

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Chemical Property of (R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

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Technology Process of (R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

There total 7 articles about (R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₈H₄₅F₇N₅O₆P

: 1308379-42-1
(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

Guidance literature:: C₃₈H₄₅F₇N₅O₆P; With trimethylsilyl bromide; In 1,2-dichloro-ethane; at 45 ℃; for 5h;

With water; In ethyl acetate; 1,2-dichloro-ethane; for 0.5h;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308376-62-6
(R)-3-(2-amino-2-phenylethyl)-1-(2-fluoro-6-(trifluoromethyl)benzyl)-6-methyl-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)pyrimidine-2,4(1H,3H)-dione

: 1308379-42-1
(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

2.1: trimethylsilyl bromide / 1,2-dichloro-ethane / 5 h / 45 °C

2.2: 0.5 h

With trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071

Reference yield:

: 1308380-26-8
((R)-2-{3-(2-fluoro-6-trifluoromethyl-benzyl)-4-methyl-2,6-dioxo-5-[4-(5-trifluoromethyl-furan-2-ylmethyl)-piperazin-1-yl]-3,6-dihydro-2H-pyrimidin-1-yl}-1-phenyl-ethyl)-carbamic acid tert-butyl ester

: 1308379-42-1
(R)-(3-((2-(3-(2-fluoro-6-(trifluoromethyl)benzyl)-4-methyl-2,6-dioxo-5-(4-((5-(trifluoromethyl)furan-2-yl)methyl)piperazin-1-yl)-2,3-dihydropyrimidin-1(6H)-yl)-1-phenylethyl)amino)propyl)phosphonic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 12 h / 95 °C

3.1: trimethylsilyl bromide / 1,2-dichloro-ethane / 5 h / 45 °C

3.2: 0.5 h

With trimethylsilyl bromide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane; acetonitrile;
DOI:10.1021/acs.jmedchem.6b01071