(Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate

Base Information

• Chemical Name: (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate
• CAS No.: 1219792-05-8
• Molecular Formula: C₂₃H₂₁O₃P
• Molecular Weight: 376.392
• Mol file: 1219792-05-8.mol

Synonyms:

Chemical Property of (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate

There total 2 articles about (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

methyl 3-hydroxy-2-methylidene-3-phenylpropionate (18020-59-2) + Diphenylphosphine oxide (4559-70-0) → (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate (1219792-05-8)

Guidance literature:

In neat (no solvent); at 60 ℃; for 24h; diastereoselective reaction; Green chemistry;

DOI:10.1039/c7gc00882a

Reference yield:

(Z)-methyl 2-(bromomethyl)-3-phenylacrylate (103669-71-2) + Diphenylphosphine oxide (4559-70-0) → (Z)-methyl-2-((diphenylphosphoryl)methyl)-3-phenylacrylate (1219792-05-8) + methyl 2-((diphenylphosphoryl)(phenyl)methyl)acrylate (1219791-92-0)

Guidance literature:

(Z)-methyl 2-(bromomethyl)-3-phenylacrylate; With potassium carbonate; In acetonitrile; at 20 ℃; for 0.25h; Inert atmosphere;

Diphenylphosphine oxide; In acetonitrile; at 80 ℃; for 12h; Inert atmosphere;

DOI:10.1080/10426500802418545

upstream raw materials:

(Z)-methyl 2-(bromomethyl)-3-phenylacrylate

Diphenylphosphine oxide

methyl 3-hydroxy-2-methylidene-3-phenylpropionate