(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

Base Information

Chemical Name:(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester
CAS No.:143122-36-5
Molecular Formula:C₃₄H₅₁N₅O₇
Molecular Weight:641.808
Hs Code.:

(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

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Chemical Property of (3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

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Technology Process of (3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

There total 6 articles about (3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3S,4S)-4-{(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionylamino}-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

: 143122-36-5
(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

Guidance literature:: With thiophenol; triethylamine; In N,N-dimethyl-formamide; for 5h; Ambient temperature;
DOI:10.1021/jm00097a010

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 143122-36-5
(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCl) / dimethylformamide / Ambient temperature

2: thiophenol, NEt₃ / dimethylformamide / 5 h / Ambient temperature

With 4-methyl-morpholine; benzotriazol-1-ol; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm00097a010

Reference yield:

: 132271-76-2
isopropyl (3S,4S)-4-amino-5-cyclohexyl-3-hydroxypentanoate*HCl

: 143122-36-5
(3S,4S)-4-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-(1H-imidazol-4-yl)-propionylamino]-5-cyclohexyl-3-hydroxy-pentanoic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCl) / dimethylformamide / 14 h / Ambient temperature

2: 4N HCl / methanol; dioxane / 1 h / Ambient temperature

3: N-methylmorpholine (NMM), 1-hydroxybenzotriazole (HOBt), N-ethyl-N'-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDCl) / dimethylformamide / Ambient temperature

4: thiophenol, NEt₃ / dimethylformamide / 5 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; benzotriazol-1-ol; thiophenol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00097a010