(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

Base Information

Chemical Name:(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid
CAS No.:123219-52-3
Molecular Formula:C₄₆H₆₄O₁₀
Molecular Weight:777.008
Hs Code.:

(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

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Chemical Property of (R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

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Technology Process of (R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

There total 7 articles about (R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1515-81-7
1-methoxy-4-(methoxymethyl)benzene

: 123219-52-3
(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 0.25 h / 20 °C

2: n-Bu₄NF / tetrahydrofuran / 3 h / 40 °C

3: 1) ozone, 2) dimethyl sulfide / CH₂Cl₂ / 1) -78 deg C, 2) room temperature, 1 h

4: m-chloroperbenzoic acid / tetrahydrofuran; H₂O / 0.5 h / 20 °C / phosphate buffer (pH: 7.0)

With dimethylsulfide; tetrabutyl ammonium fluoride; ozone; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water;
DOI:10.1007/BF00953721

Reference yield:

: 123219-41-0
(2R,3S,4R,5R)-3-Benzyloxy-5-(tert-butyl-dimethyl-silanyloxy)-2,4-dimethyl-heptanal

: 123219-52-3
(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 64.2 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C / 1) 30 min, 2) 15 min

2: LiAlH₄ / diethyl ether / 0.17 h

3: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 0.25 h / 20 °C

4: n-Bu₄NF / tetrahydrofuran / 3 h / 40 °C

5: 1) ozone, 2) dimethyl sulfide / CH₂Cl₂ / 1) -78 deg C, 2) room temperature, 1 h

6: m-chloroperbenzoic acid / tetrahydrofuran; H₂O / 0.5 h / 20 °C / phosphate buffer (pH: 7.0)

With lithium aluminium tetrahydride; dimethylsulfide; tetrabutyl ammonium fluoride; ozone; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1007/BF00953721

Reference yield:

: 123219-53-4
(R)-4-Benzyloxy-4-[(4R,5S,6R)-2,2,5-trimethyl-6-((S)-1-methyl-allyl)-[1,3]dioxan-4-yl]-pentanoic acid methoxymethyl ester

: 123219-52-3
(R)-2-((4S,5S,6R)-6-{(R)-1-Benzyloxy-2-[(2R,4R,5R)-4-((1R,2S,3S,4R)-2-benzyloxy-4-hydroxy-1,3-dimethyl-hexyl)-2-(4-methoxy-phenyl)-[1,3]dioxan-5-yl]-1-methyl-ethyl}-2,2,5-trimethyl-[1,3]dioxan-4-yl)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 64.2 percent / lithium diisopropylamide / tetrahydrofuran / -78 °C / 1) 30 min, 2) 15 min

2: LiAlH₄ / diethyl ether / 0.17 h

3: 2,3-dichloro-5,6-dicyano-1,4-benzoquinone / CH₂Cl₂ / 0.25 h / 20 °C

4: n-Bu₄NF / tetrahydrofuran / 3 h / 40 °C

5: 1) ozone, 2) dimethyl sulfide / CH₂Cl₂ / 1) -78 deg C, 2) room temperature, 1 h

6: m-chloroperbenzoic acid / tetrahydrofuran; H₂O / 0.5 h / 20 °C / phosphate buffer (pH: 7.0)

With lithium aluminium tetrahydride; dimethylsulfide; tetrabutyl ammonium fluoride; ozone; 3-chloro-benzenecarboperoxoic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; dichloromethane; water;
DOI:10.1007/BF00953721