Technology Process of C28H25BrN8O6S
There total 6 articles about C28H25BrN8O6S which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C24H24N6O6S;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
for 0.25h;
5-Bromo-2-chloropyrimidine;
In
tetrahydrofuran; N,N-dimethyl-formamide; mineral oil;
at 60 ℃;
for 2h;
DOI:10.1021/jm3009103
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: thionyl chloride / 3 h / 0 - 20 °C
2.1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 40 - 45 °C
2.2: 24 h / 20 - 32 °C
3.1: sodium / methanol / 18 h / 0 - 20 °C
3.2: 4 h / 20 °C
4.1: trichlorophosphate / N,N-dimethyl-aniline / 2 h / 130 °C
5.1: dimethyl sulfoxide / 48 h / 20 °C
6.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 40 °C
6.2: 70 h / 100 °C
7.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h
7.2: 2 h / 60 °C
With
thionyl chloride; potassium tert-butylate; sodium; sodium hydride; trichlorophosphate;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dimethyl sulfoxide; N,N-dimethyl-aniline; mineral oil;
DOI:10.1021/jm3009103
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dimethyl sulfoxide / 48 h / 20 °C
2.1: potassium tert-butylate / 1,2-dimethoxyethane / 0.17 h / 40 °C
2.2: 70 h / 100 °C
3.1: sodium hydride / tetrahydrofuran; mineral oil / 0.25 h
3.2: 2 h / 60 °C
With
potassium tert-butylate; sodium hydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; dimethyl sulfoxide; mineral oil;
DOI:10.1021/jm3009103
