HP-C₈ chloride

Base Information

• Chemical Name: HP-C₈ chloride
• CAS No.: 1271727-89-9
• Molecular Formula: C₄₃H₆₆ClFN₃O₄*Cl
• Molecular Weight: 778.919
• Mol file: 1271727-89-9.mol

Synonyms:

Chemical Property of HP-C₈ chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of HP-C₈ chloride

There total 6 articles about HP-C₈ chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.3%

C24H28ClFN2O3 (853994-08-8) + N-(carboxymethyl)-N-methyl-N-octyloctan-1-aminium trifluoroacetate → HP-C8 chloride (1271727-89-9)

Guidance literature:

N-(carboxymethyl)-N-methyl-N-octyloctan-1-aminium trifluoroacetate; With HATU; In N,N-dimethyl-formamide; Cooling with ice;

C₂₄H₂₈ClFN₂O₃; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;

In methanol;

DOI:10.1021/jm101530j

Reference yield:

tert-butyl 2-(dioctylamino)acetate (1271727-74-2) → HP-C8 chloride (1271727-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloromethane / 20 °C

2.1: dichloromethane / 20 °C / Cooling with ice

3.1: HATU / N,N-dimethyl-formamide / Cooling with ice

3.3: Amberlite IRA-400Cl

With HATU; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm101530j

Reference yield:

haloperidol (52-86-8) → HP-C8 chloride (1271727-89-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dmap / dichloromethane / 0.5 h / Cooling with ice

1.2: 25 h / 20 °C / Cooling with ice

2.1: trifluoroacetic acid / dichloromethane / 4 h / Cooling with ice

3.1: HATU / N,N-dimethyl-formamide / Cooling with ice

3.3: Amberlite IRA-400Cl

With dmap; HATU; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm101530j

upstream raw materials:

C₂₄H₂₈ClFN₂O₃

C₂₉H₃₆ClFN₂O₅

tert-butyl 2-(dioctylamino)acetate

1-bromo-octane