Technology Process of Benzoic acid (R)-3-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyl-octahydro-inden-1-yl)-butyl ester
There total 10 articles about Benzoic acid (R)-3-((1R,3aR,4S,7aR)-4-hydroxy-7a-methyl-octahydro-inden-1-yl)-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: t-BuOK / tetrahydrofuran / 63 h / Ambient temperature
2: 70 percent / 0.813M BF3*Et2O / CH2Cl2 / 2 h
3: 77 percent / H2 / 5 percent Pd/C / ethyl acetate / 735.5 Torr
4: 1.) pyridine / 1.) 0 deg C, 1 h; 2.) water, 30 min
With
pyridine; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(84)80011-3
- Guidance literature:
-
Multi-step reaction with 10 steps
2: 82 percent / H2 / 10percent Rh/C / ethyl acetate / 735.5 Torr
3: 57 percent / trifluoroperacetic acid, disodium hydrogen phosphate / CH2Cl2 / 1.) 0 deg C, 1 h; 2.) RT, 30 h
4: 80 percent / iodotrimethylsilane / CCl4 / 5 h / Ambient temperature
5: 97 percent / pyridinium chlorochromate; / CH2Cl2 / 2.5 h / Ambient temperature
6: 87 percent / 25percent NaOMe / methanol / 3.5 h
7: t-BuOK / tetrahydrofuran / 63 h / Ambient temperature
8: 70 percent / 0.813M BF3*Et2O / CH2Cl2 / 2 h
9: 77 percent / H2 / 5 percent Pd/C / ethyl acetate / 735.5 Torr
10: 1.) pyridine / 1.) 0 deg C, 1 h; 2.) water, 30 min
With
pyridine; disodium hydrogenphosphate; trimethylsilyl iodide; trifluoroacetyl peroxide; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; sodium methylate; pyridinium chlorochromate;
palladium on activated charcoal; Rh on carbon;
In
tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(84)80011-3
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 97 percent / pyridinium chlorochromate; / CH2Cl2 / 2.5 h / Ambient temperature
2: 87 percent / 25percent NaOMe / methanol / 3.5 h
3: t-BuOK / tetrahydrofuran / 63 h / Ambient temperature
4: 70 percent / 0.813M BF3*Et2O / CH2Cl2 / 2 h
5: 77 percent / H2 / 5 percent Pd/C / ethyl acetate / 735.5 Torr
6: 1.) pyridine / 1.) 0 deg C, 1 h; 2.) water, 30 min
With
pyridine; boron trifluoride diethyl etherate; potassium tert-butylate; hydrogen; sodium methylate; pyridinium chlorochromate;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; ethyl acetate;
DOI:10.1016/0040-4020(84)80011-3
