(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

Base Information

Chemical Name:(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester
CAS No.:887907-15-5
Molecular Formula:C₂₂H₂₅Cl₂N₃O₅S₂
Molecular Weight:546.496
Hs Code.:

(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

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Chemical Property of (S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

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Technology Process of (S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

There total 3 articles about (S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 887907-14-4
(S)-2-{[2-(4,5-Dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-3-(4-nitro-phenyl)-propionic acid methyl ester

: 887907-15-5
(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

Guidance literature:: With ammonium chloride; zinc; In methanol; for 3h; Heating;
DOI:10.1016/j.bmcl.2003.11.063

Reference yield:

: 887903-71-1
2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid ethyl ester

: 887907-15-5
(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: aq. LiOH / methanol / 60 °C

2: EDAC; HOBt; i-Pr₂NEt / CH₂Cl₂ / 23 °C

3: Zn; NH₄Cl / methanol / 3 h / Heating

With lithium hydroxide; ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2003.11.063

Reference yield:

: 887903-72-2
2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carboxylic acid

: 887907-15-5
(S)-3-(4-Amino-phenyl)-2-{[2-(4,5-dichloro-thiophene-2-sulfonyl)-2-aza-bicyclo[2.2.2]octane-3-carbonyl]-amino}-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: EDAC; HOBt; i-Pr₂NEt / CH₂Cl₂ / 23 °C

2: Zn; NH₄Cl / methanol / 3 h / Heating

With ammonium chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; zinc; In methanol; dichloromethane;
DOI:10.1016/j.bmcl.2003.11.063