C₄₄H₅₃FN₈O₆S

Base Information

Chemical Name:C₄₄H₅₃FN₈O₆S
CAS No.:1335317-44-6
Molecular Formula:C₄₄H₅₃FN₈O₆S
Molecular Weight:841.019
Hs Code.:

C<sub>44</sub>H<sub>53</sub>FN<sub>8</sub>O<sub>6</sub>S

Synonyms:

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Chemical Property of C₄₄H₅₃FN₈O₆S

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Technology Process of C₄₄H₅₃FN₈O₆S

There total 9 articles about C₄₄H₅₃FN₈O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869569-77-7
1-(4-bromo-2-fluorophenyl)-2-bromo-1-ethanone

: 1335317-44-6
C₄₄H₅₃FN₈O₆S

Guidance literature:: Multi-step reaction with 4 steps

2: palladium diacetate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; sodium hydrogencarbonate / water; isopropyl alcohol / 120 °C / Microwave irradiation

3: trifluoroacetic acid / dichloromethane / 20 °C

4: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane

With sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; palladium diacetate; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; isopropyl alcohol; 2: |Suzuki Coupling;
DOI:10.1021/ml300461f

Reference yield:

: 1313207-05-4
(2S,4S)-tert-butyl 2-(4,5-diiodo-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate

: 1335317-44-6
C₄₄H₅₃FN₈O₆S

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium chloride / tetrahydrofuran / 0.17 h / 20 °C

1.2: 0.5 h / -20 °C

1.3: 3 h / -20 - 20 °C

2.1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / N,N-dimethyl-formamide / 16 h / 80 °C / Inert atmosphere

3.1: N-iodo-succinimide / dichloromethane / 1.5 h / 0 - 20 °C

4.1: copper(l) iodide; sodiumsulfide nonahydrate / dimethyl sulfoxide / 3 h / 20 - 150 °C

5.1: palladium diacetate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; sodium hydrogencarbonate / water; isopropyl alcohol / 120 °C / Microwave irradiation

6.1: trifluoroacetic acid / dichloromethane / 20 °C

7.1: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-iodo-succinimide; copper(l) iodide; sodiumsulfide nonahydrate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; palladium diacetate; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol; 2.1: |Sonogashira Cross-Coupling / 5.1: |Suzuki Coupling;
DOI:10.1021/ml300461f

Reference yield:

: C₁₉H₂₃BrFN₃O₂

: 1335317-44-6
C₄₄H₅₃FN₈O₆S

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; sodium hydrogencarbonate / water; isopropyl alcohol / 120 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 20 °C

3: N-ethyl-N,N-diisopropylamine; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / dichloromethane

With sodium 2′-dicyclohexylphosphino-2,6-dimethoxy-1,1′-biphenyl-3-sulfonate hydrate; palladium diacetate; sodium hydrogencarbonate; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; isopropyl alcohol; 1: |Suzuki Coupling;
DOI:10.1021/ml300461f