dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate

Base Information

• Chemical Name: dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate
• CAS No.: 1335054-43-7
• Molecular Formula: C₄₂H₅₇N₅O₈
• Molecular Weight: 759.943
• Mol file: 1335054-43-7.mol

Synonyms:

Chemical Property of dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate

There total 2 articles about dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[4-(methylcarbamoyl)phenyl]boronic acid + [4-[(2S,3S,5S)-3-hydroxy-2,5-bis[(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanamido]-6-phenylhexyl]phenyl] trifluoromethanesulfonate (1335054-17-5) → dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate (1335054-43-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1021/jm201109t

Reference yield:

C34H50N4O8 → dimethyl (2S,2'S)-1,1'-((2S,3S,5S)-3-hydroxy-1-(4'-(methylcarbamoyl)biphenyl-4-yl)-6-phenylhexane-2,5-diyl)bis(azanediyl)bis-(3,3-dimethyl-1-oxobutane-2,1-diyl)dicarbamate (1335054-43-7)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap / dichloromethane / 2 h / 40 °C / Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C / Inert atmosphere

With dmap; bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling;

DOI:10.1021/jm201109t

upstream raw materials:

[4-[(2S,3S,5S)-3-hydroxy-2,5-bis[(S)-2-(methoxycarbonylamino)-3,3-dimethylbutanamido]-6-phenylhexyl]phenyl] trifluoromethanesulfonate