1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol

Base Information

• Chemical Name: 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol
• CAS No.: 1096491-68-7
• Molecular Formula: C₃₃H₂₈N₂O
• Molecular Weight: 468.598
• Mol file: 1096491-68-7.mol

Synonyms:

Chemical Property of 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol

There total 4 articles about 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-diphenyl-1H-indole (3469-20-3) → 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol (1096491-68-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / Cooling with ice

1.2: 21 h / 20 °C

2.1: bismuth(III) chloride / acetonitrile; cyclohexane / Reflux

With bismuth(III) chloride; potassium hydroxide; In cyclohexane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201301742

Reference yield:

aniline (62-53-3) → 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol (1096491-68-7)

Guidance literature:

Multi-step reaction with 4 steps

1.1: hydrogenchloride; sodium nitrite / acetonitrile; water / 0.5 h / -5 - 0 °C

1.2: 0 °C

2.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; silver hexafluoroantimonate / methanol / 90 °C / Schlenk technique; Inert atmosphere

3.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / Cooling with ice

3.2: 21 h / 20 °C

4.1: bismuth(III) chloride / acetonitrile; cyclohexane / Reflux

With hydrogenchloride; bismuth(III) chloride; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; potassium hydroxide; sodium nitrite; In methanol; cyclohexane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201301742

Reference yield:

(E)-1-phenyl-2-(pyrrolidin-1-yl)diazene (36719-71-8) → 1-(2,3-diphenyl-1H-indol-1-yl)-3-(naphthalen-1-ylamino)propan-2-ol (1096491-68-7)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; silver hexafluoroantimonate / methanol / 90 °C / Schlenk technique; Inert atmosphere

2.1: potassium hydroxide / N,N-dimethyl-formamide / 1 h / Cooling with ice

2.2: 21 h / 20 °C

3.1: bismuth(III) chloride / acetonitrile; cyclohexane / Reflux

With bismuth(III) chloride; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; copper(II) acetate monohydrate; potassium hydroxide; In methanol; cyclohexane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1002/anie.201301742

upstream raw materials:

2,3-diphenyl-1H-indole

aniline

C₂₃H₁₉NO

1-amino-naphthalene