4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester

Base Information

• Chemical Name: 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester
• CAS No.: 882979-04-6
• Molecular Formula: C₂₃H₂₇N₃S₂
• Molecular Weight: 409.619
• Mol file: 882979-04-6.mol

Synonyms:

Chemical Property of 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester

There total 4 articles about 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + carbon disulfide (75-15-0,12122-00-8) + 4-bromo-2-phenyl-2-p-tolylbutyronitrile (24051-20-5) → 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester (882979-04-6)

Guidance literature:

1-methyl-piperazine; With potassium phosphate; In acetone; at 20 ℃; for 0.25h;

carbon disulfide; In acetone;

4-bromo-2-phenyl-2-p-tolylbutyronitrile; In acetone;

DOI:10.1002/ardp.201000259

Reference yield:

bromo-phenyl-acetonitrile (5798-79-8) → 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester (882979-04-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 20 °C / Heating

2: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 6 h / Reflux

3: potassium phosphate / acetone / 0.25 h / 20 °C

With aluminum (III) chloride; potassium phosphate; tetrabutylammomium bromide; potassium carbonate; In acetone; acetonitrile; 1: Friedel Crafts arylation;

DOI:10.1002/ardp.201000259

Reference yield:

phenylacetonitrile (140-29-4) → 4-methylpiperazine-1-carbodithioic acid 3-cyano-3-phenyl-3-(4-methylphenyl)propyl ester (882979-04-6)

Guidance literature:

Multi-step reaction with 4 steps

1: bromine / 1 h / 105 - 110 °C

2: aluminum (III) chloride / 20 °C / Heating

3: tetrabutylammomium bromide; potassium carbonate / acetonitrile / 6 h / Reflux

4: potassium phosphate / acetone / 0.25 h / 20 °C

With aluminum (III) chloride; potassium phosphate; tetrabutylammomium bromide; bromine; potassium carbonate; In acetone; acetonitrile; 2: Friedel Crafts arylation;

DOI:10.1002/ardp.201000259

upstream raw materials:

1-methyl-piperazine

carbon disulfide

4-bromo-2-phenyl-2-p-tolylbutyronitrile

bromo-phenyl-acetonitrile