(2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

Base Information

Chemical Name:(2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine
CAS No.:1358526-47-2
Molecular Formula:C₁₉H₂₇NO₄
Molecular Weight:333.428
Hs Code.:

Synonyms:

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Chemical Property of (2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

Chemical Property:

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Technology Process of (2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

There total 12 articles about (2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₉H₄₃NO₄Si

: 1358526-47-2
(2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

Guidance literature:: Multi-step reaction with 11 steps

1: magnesium / methanol / 2 h / 20 °C

2: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 °C

3: platinum(IV) oxide; hydrogen / tetrahydrofuran / 3 h / 20 °C

4: diethyl ether / 0 °C

5: 20 % Pd(OH)2/C; hydrogen / methanol / 12 h / 20 °C / 7600.51 Torr / Autoclave

6: potassium carbonate / TETRAHYDROPYRANE; water / 2 h / 0 °C

7: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 2.08 h / 0 - 20 °C

8: sodium tetrahydroborate / dimethyl sulfoxide / 1 h / 90 °C

9: hydrogenchloride / tetrahydrofuran; water / 1 h / 0 - 20 °C

10: Jones reagent / acetone / 2 h / 0 - 20 °C

11: ethyl acetate / 0.5 h / 0 °C

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; Jones reagent; carbon tetrabromide; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; magnesium; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; TETRAHYDROPYRANE; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone; toluene; 10: Jones oxidation;
DOI:10.1021/jo202350z

Reference yield:

: 910106-36-4
{4-[3-(tert-butyl-dimethyl-silanyloxy)-propyl]-5-isopropyl-1,3,4,9,9a,10a-hexahydro-2H,4bH-10-oxa-4a-aza-indeno[1,2-a]inden-2-yl}-methanol

: 1358526-47-2
(2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

Guidance literature:: Multi-step reaction with 8 steps

1: diethyl ether / 0 °C

2: 20 % Pd(OH)2/C; hydrogen / methanol / 12 h / 20 °C / 7600.51 Torr / Autoclave

3: potassium carbonate / TETRAHYDROPYRANE; water / 2 h / 0 °C

4: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 2.08 h / 0 - 20 °C

5: sodium tetrahydroborate / dimethyl sulfoxide / 1 h / 90 °C

6: hydrogenchloride / tetrahydrofuran; water / 1 h / 0 - 20 °C

7: Jones reagent / acetone / 2 h / 0 - 20 °C

8: ethyl acetate / 0.5 h / 0 °C

With hydrogenchloride; sodium tetrahydroborate; Jones reagent; carbon tetrabromide; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; In tetrahydrofuran; TETRAHYDROPYRANE; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone; 7: Jones oxidation;
DOI:10.1021/jo202350z

Reference yield:

: C₂₉H₄₅NO₄Si

: 1358526-47-2
(2R,4S,6S)-(-)-N-benzoxycalboyl-4,6-dimethyl-3-methylesterpropylpiperidine

Guidance literature:: Multi-step reaction with 10 steps

1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 0 °C

2: platinum(IV) oxide; hydrogen / tetrahydrofuran / 3 h / 20 °C

3: diethyl ether / 0 °C

4: 20 % Pd(OH)2/C; hydrogen / methanol / 12 h / 20 °C / 7600.51 Torr / Autoclave

5: potassium carbonate / TETRAHYDROPYRANE; water / 2 h / 0 °C

6: carbon tetrabromide; triethylamine; triphenylphosphine / dichloromethane / 2.08 h / 0 - 20 °C

7: sodium tetrahydroborate / dimethyl sulfoxide / 1 h / 90 °C

8: hydrogenchloride / tetrahydrofuran; water / 1 h / 0 - 20 °C

9: Jones reagent / acetone / 2 h / 0 - 20 °C

10: ethyl acetate / 0.5 h / 0 °C

With hydrogenchloride; platinum(IV) oxide; sodium tetrahydroborate; Jones reagent; carbon tetrabromide; 20 % Pd(OH)2/C; hydrogen; potassium carbonate; triethylamine; triphenylphosphine; sodium bis(2-methoxyethoxy)aluminium dihydride; In tetrahydrofuran; TETRAHYDROPYRANE; methanol; diethyl ether; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; acetone; toluene; 9: Jones oxidation;
DOI:10.1021/jo202350z