L-Phenylalanine, 3-carboxy-

Base Information

• Chemical Name: L-Phenylalanine, 3-carboxy-
• CAS No.: 13861-02-4
• Molecular Formula: C10H11NO4
• Molecular Weight: 209.19900
• Mol file: 13861-02-4.mol

Synonyms:3-carboxy-L-phenylalanine;3-(3-carboxyphenyl)alanine;3-((S)-2-Amino-2-carboxy-ethyl)-benzoic acid;3-(3-Carboxyphenyl)alanin;L-3-(3-Carboxy-phenyl)-alanin;3-(3-carboxyphenyl) alanine;3-Carboxy-L-phenylalanin;

Chemical Property of L-Phenylalanine, 3-carboxy-

Chemical Property:

• PSA: 100.62000
• LogP: 1.03950

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of L-Phenylalanine, 3-carboxy-

There total 6 articles about L-Phenylalanine, 3-carboxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

(S)-2-amino-3-(3-(methoxycarbonyl)phenyl)propanoic acid (167549-71-5) → (S)-3-(2-amino-2-carboxyethyl)benzoic acid (13861-02-4)

Guidance literature:

With lithium hydroxide monohydrate; In water; at 20 ℃; for 18h;

DOI:10.1021/acs.jmedchem.8b01007

Reference yield:

3-cyano-(D,L)-phenylalanine (57213-48-6) → (S)-3-(2-amino-2-carboxyethyl)benzoic acid (13861-02-4)

Guidance literature:

With hydrogenchloride; In water; Reflux;

DOI:10.1007/s11095-012-0966-3

Reference yield:

C20H29NO6 → (S)-3-(2-amino-2-carboxyethyl)benzoic acid (13861-02-4)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid; methoxybenzene / dichloromethane / 18 h / 20 °C

2: lithium hydroxide monohydrate / water / 18 h / 20 °C

With lithium hydroxide monohydrate; methoxybenzene; trifluoroacetic acid; In dichloromethane; water;

DOI:10.1021/acs.jmedchem.8b01007

upstream raw materials:

3-cyano-(D,L)-phenylalanine

(S)-2-amino-3-(3-(methoxycarbonyl)phenyl)propanoic acid

methyl 3-bromobenzoate

m-bromobenzoic acid

Downstream raw materials:

(S)-3-(2-carboxy-2-((S)-3-(1-methoxy-4-methyl-1-oxopentan-2-yl)ureido)ethyl)benzoic acid

3-((3,4-dihydroxyphenethyl)carbamoyl)-L-phenylalanine