Technology Process of 2H-Tetrazole-2-pentanamide, 5-[4-(4-phenylbutoxy)phenyl]-
There total 8 articles about 2H-Tetrazole-2-pentanamide, 5-[4-(4-phenylbutoxy)phenyl]- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 70 percent / K2CO3, KI / butan-2-one / 20 h / Heating
2: 40 percent / 1.) 5 N aq. NaOH, 2.) conc. aq. HCl / H2O; methanol / 1.) reflux, 3 h
3: thionyl chloride / Ambient temperature
4: NH4OH
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; thionyl chloride; potassium carbonate; potassium iodide;
In
methanol; water; butanone;
DOI:10.1021/jm00085a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, RT, overnight
2: 50 percent / tributyltin azide / 1,2-diethoxy-ethane / 72 h / Heating
3: 70 percent / K2CO3, KI / butan-2-one / 20 h / Heating
4: 40 percent / 1.) 5 N aq. NaOH, 2.) conc. aq. HCl / H2O; methanol / 1.) reflux, 3 h
5: thionyl chloride / Ambient temperature
6: NH4OH
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; thionyl chloride; tributyltin azide; sodium hydride; potassium carbonate; potassium iodide;
In
methanol; monoethylene glycol diethyl ether; water; butanone;
DOI:10.1021/jm00085a004
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, RT, overnight
2: 50 percent / tributyltin azide / 1,2-diethoxy-ethane / 72 h / Heating
3: 70 percent / K2CO3, KI / butan-2-one / 20 h / Heating
4: 40 percent / 1.) 5 N aq. NaOH, 2.) conc. aq. HCl / H2O; methanol / 1.) reflux, 3 h
5: thionyl chloride / Ambient temperature
6: NH4OH
With
hydrogenchloride; ammonium hydroxide; sodium hydroxide; thionyl chloride; tributyltin azide; sodium hydride; potassium carbonate; potassium iodide;
In
methanol; monoethylene glycol diethyl ether; water; butanone;
DOI:10.1021/jm00085a004
