C₂₁H₁₉F₃O₃

Base Information

Chemical Name:C₂₁H₁₉F₃O₃
CAS No.:1002129-34-1
Molecular Formula:C₂₁H₁₉F₃O₃
Molecular Weight:376.375
Hs Code.:

C<sub>21</sub>H<sub>19</sub>F<sub>3</sub>O<sub>3</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂₁H₁₉F₃O₃

Chemical Property:

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Technology Process of C₂₁H₁₉F₃O₃

There total 4 articles about C₂₁H₁₉F₃O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1369534-91-7
ethyl (2E,4Z)-5-(4-propoxyphenyl)-5-(4-trifluoromethylphenyl)-2,4-pentadienoate

: 1002129-34-1
C₂₁H₁₉F₃O₃

Guidance literature:: ethyl (2E,4Z)-5-(4-propoxyphenyl)-5-(4-trifluoromethylphenyl)-2,4-pentadienoate; With lithium hydroxide; In tetrahydrofuran; methanol; water; at 20 ℃; for 4h; Inert atmosphere;

With hydrogenchloride; In water; at 0 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/jm300101n

Reference yield:

: 1002127-15-2
ethyl (E)-5,5-dibromo-2,4-pentadienoate

: 1002129-34-1
C₂₁H₁₉F₃O₃

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 6 h / 70 °C / Inert atmosphere

2.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate / 1,4-dioxane; water / 4.5 h / 70 °C / Inert atmosphere

3.1: triphenylphosphine; diethylazodicarboxylate / toluene / 13 h / 20 °C / Inert atmosphere

4.1: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C / Inert atmosphere

4.2: 0.5 h / 0 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; trifuran-2-yl-phosphane; sodium carbonate; triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; 1,4-dioxane; methanol; water; toluene; 1.1: Suzuki coupling / 2.1: Suzuki coupling / 3.1: Mitsunobu reaction;
DOI:10.1021/jm300101n

Reference yield:

: 1002128-15-5
ethyl (2E,4Z)-5-(4-hydroxyphenyl)-5-(4-trifluoromethylphenyl)-2,4-pentadienoate

: 1002129-34-1
C₂₁H₁₉F₃O₃

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; diethylazodicarboxylate / toluene / 13 h / 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; methanol; water / 4 h / 20 °C / Inert atmosphere

2.2: 0.5 h / 0 °C / Inert atmosphere

With triphenylphosphine; lithium hydroxide; diethylazodicarboxylate; In tetrahydrofuran; methanol; water; toluene; 1.1: Mitsunobu reaction;
DOI:10.1021/jm300101n