2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

Base Information

• Chemical Name: 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone
• CAS No.: 1261115-58-5
• Molecular Formula: C₂₂H₂₃F₂N₅O
• Molecular Weight: 411.454
• Mol file: 1261115-58-5.mol

Synonyms:

Chemical Property of 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone

There total 6 articles about 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C27H31F2N5O3 → 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone (1261115-58-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

DOI:10.1021/jm300041e

Reference yield:

C18H16FN3O2 (1261118-48-2) → 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone (1261115-58-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium carbonate; potassium iodide / N,N-dimethyl-formamide / 48 h / 20 - 40 °C

2.1: methanesulfonic acid; acetic acid / 12 h / Sealed tube; Heating

3.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

4.1: bromine; acetic acid / dichloromethane / 0.5 h / 20 °C

5.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 °C

5.2: 150 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; methanesulfonic acid; bromine; potassium carbonate; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; potassium iodide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 5.1: Buchwald-Hartwig amination / 5.2: Buchwald-Hartwig amination;

DOI:10.1021/jm300041e

Reference yield:

C22H22FN3O2 (1261118-40-4) → 2-amino-1-(2-(4-fluorophenyl)-3-(4-fluorophenylamino)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-ethanone (1261115-58-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: methanesulfonic acid; acetic acid / 12 h / Sealed tube; Heating

2.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 20 °C

3.1: bromine; acetic acid / dichloromethane / 0.5 h / 20 °C

4.1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 20 °C

4.2: 150 °C / Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 20 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; methanesulfonic acid; bromine; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; 4.1: Buchwald-Hartwig amination / 4.2: Buchwald-Hartwig amination;

DOI:10.1021/jm300041e

upstream raw materials:

C₁₈H₁₆FN₃O₂

C₂₂H₂₂FN₃O₂

C₁₄H₁₆FN₃

tert-butyl 2-(3-bromo-2-(4-fluorophenyl)-6,6-dimethyl-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-oxoethylcarbamate