Technology Process of ethyl 1-{[3-chlorophenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinoline-4-carboxylate
There total 6 articles about ethyl 1-{[3-chlorophenyl]amino}-5,6,7,8-tetrahydro-5,8-methanoisoquinoline-4-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: chloro-trimethyl-silane; sodium iodide / acetonitrile / 19 h / 20 - 50 °C
2: trichlorophosphate / 1 h / 100 °C
3: 7 h / 180 °C
With
chloro-trimethyl-silane; sodium iodide; trichlorophosphate;
In
acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: N-Bromosuccinimide / chloroform / 36 h / 20 °C
2: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 15 h / 100 °C
3: chloro-trimethyl-silane; sodium iodide / acetonitrile / 19 h / 20 - 50 °C
4: trichlorophosphate / 1 h / 100 °C
5: 7 h / 180 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; chloro-trimethyl-silane; palladium diacetate; triethylamine; sodium iodide; trichlorophosphate;
In
chloroform; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 3-chloro-benzenecarboperoxoic acid / chloroform / 2 h / 20 °C / Cooling with ice
2: sodium methylate / methanol / 15 h / Reflux
3: N-Bromosuccinimide / chloroform / 36 h / 20 °C
4: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; triethylamine / N,N-dimethyl-formamide / 15 h / 100 °C
5: chloro-trimethyl-silane; sodium iodide / acetonitrile / 19 h / 20 - 50 °C
6: trichlorophosphate / 1 h / 100 °C
7: 7 h / 180 °C
With
1,1'-bis-(diphenylphosphino)ferrocene; N-Bromosuccinimide; chloro-trimethyl-silane; sodium methylate; palladium diacetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; sodium iodide; trichlorophosphate;
In
methanol; chloroform; N,N-dimethyl-formamide; acetonitrile;
