1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

Base Information

Chemical Name:1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)
CAS No.:139340-17-3
Molecular Formula:C₆H₁₅N*C₃₆H₃₉N₄O₉P
Molecular Weight:803.893
Hs Code.:

1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

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Technology Process of 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

There total 5 articles about 1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.7%

: 15715-58-9
triethylamine carbonate

: 139212-47-8
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one

: 139340-17-3
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

Guidance literature:: With 4-methyl-morpholine; 1,2,4-Triazole; phosphorus trichloride; 1) 10 min RT, 2) H₂O;
DOI:10.1002/hlca.19910740821

Reference yield:

: 87202-41-3
6-amino-1-(2'-deoxy-β-D-erythro-pentofuranosyl)-1H-imidazo<4,5-c>pyridin-4(5H)-one

: 139340-17-3
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

Guidance literature:: Multi-step reaction with 4 steps

1: 73 percent / pyridine / 3 h / Heating

2: 72 percent / 2M NaOH / methanol / 0.33 h / 0 °C

3: 47.5 percent / pyridine, 4-dimethylaminopyridine / 3 h / Ambient temperature

4: 39.7 percent / 1) PCl₃, N-methylmorpholine, 1,2,4-triazole / 1) 10 min RT, 2) H₂O

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; dmap; sodium hydroxide; phosphorus trichloride; In methanol;
DOI:10.1002/hlca.19910740821

Reference yield:

: 139212-45-6
1-<2'-deoxy-3',5'-bis-O-(2-methylpropionyl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one

: 139340-17-3
1-<2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl>-6-<(2-methylpropionyl)amino>-1H-imidazo<4,5-c>pyridin-4(5H)-one 3'-(triethylammonium phosphonate)

Guidance literature:: Multi-step reaction with 3 steps

1: 72 percent / 2M NaOH / methanol / 0.33 h / 0 °C

2: 47.5 percent / pyridine, 4-dimethylaminopyridine / 3 h / Ambient temperature

3: 39.7 percent / 1) PCl₃, N-methylmorpholine, 1,2,4-triazole / 1) 10 min RT, 2) H₂O

With 4-methyl-morpholine; pyridine; 1,2,4-Triazole; dmap; sodium hydroxide; phosphorus trichloride; In methanol;
DOI:10.1002/hlca.19910740821