Technology Process of (S)-ethyl 2-benzyl-2-fluoro-3-oxobutanoate
There total 2 articles about (S)-ethyl 2-benzyl-2-fluoro-3-oxobutanoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluorormethanesulfonic acid; (S)-N1-(2-adamantyl)-3,3-dimethylbutane-1,2-diamine; 1-fluoro-2,4,6-trimethylpyridinium trifluoromethanesulfonate;
In
methanol;
at 20 ℃;
for 36h;
Reagent/catalyst;
Overall yield = 86 %; enantioselective reaction;
DOI:10.1039/c6sc03109a
- Guidance literature:
-
Ethyl 2-benzylacetoacetate;
With
copper(II) bis(trifluoromethanesulfonate); (S)-N-[2-(2,4,6-triisopropylbenzylamino)phenyl]-S-methyl-S-phenylsulfoximine;
In
diethyl ether;
at 20 ℃;
for 0.0833333h;
Inert atmosphere;
With
N-fluorobis(benzenesulfon)imide;
In
diethyl ether;
at -78 - 20 ℃;
for 16h;
optical yield given as %ee;
enantioselective reaction;
Inert atmosphere;
DOI:10.1002/ejoc.200900467
