1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Base Information

Chemical Name:1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide
CAS No.:1588395-94-1
Molecular Formula:C₂₄H₁₉F₂N₅O₅S₂
Molecular Weight:559.574
Hs Code.:

1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

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Chemical Property of 1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

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Technology Process of 1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

There total 3 articles about 1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1588396-86-4
methyl 1-(3,4-difluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxylate 5,5-dioxide

: 1588395-94-1
1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; water / methanol / 1 h / Reflux

2: thionyl chloride / 1 h / Reflux

3: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; water; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401688h

Reference yield:

: C₁₂H₁₁NO₆S

: 1588395-94-1
1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 4 h / Reflux

2: sodium hydroxide; water / methanol / 1 h / Reflux

3: thionyl chloride / 1 h / Reflux

4: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; water; triethylamine; sodium hydroxide; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401688h

Reference yield:

: 1588396-37-5
1-(3,4-difluorophenyl)-4-methyl-1,4-dihydropyrazolo[4,3-c]-[1,2]benzothiazine-3-carboxylic acid 5,5-dioxide

: 1588395-94-1
1-(3,4-difluorophenyl)-4-methyl-N-{4-[(methylsulfonyl)-amino]phenyl}-1,4-dihydropyrazolo[4,3-c][1,2]benzothiazine-3-carboxamide 5,5-dioxide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1 h / Reflux

2: triethylamine / N,N-dimethyl-formamide / 24 h / 40 °C / Inert atmosphere

With thionyl chloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1021/jm401688h