Technology Process of C22H22N2O3
There total 7 articles about C22H22N2O3 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium phosphate; bis(tri-t-butylphosphine)palladium(0);
In
N,N-dimethyl acetamide;
at 80 ℃;
for 18h;
DOI:10.1016/j.bmcl.2014.04.087
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C
1.2: 3 h / 20 °C
2.1: bis(tri-t-butylphosphine)palladium(0); potassium phosphate / N,N-dimethyl acetamide / 18 h / 80 °C
With
potassium phosphate; bis(tri-t-butylphosphine)palladium(0); sodium hydride;
In
tetrahydrofuran; N,N-dimethyl acetamide;
DOI:10.1016/j.bmcl.2014.04.087
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium ethanolate / 2 h / 0 - 20 °C
2.1: hydrazine / ethanol / 1.5 h / 80 °C
3.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C
4.1: potassium tert-butylate / toluene / 1 h / Reflux
5.1: lithium chloride / water; dimethyl sulfoxide / 10 h / 115 °C
6.1: sodium hydride / tetrahydrofuran / 0 °C
6.2: 3 h / 20 °C
7.1: bis(tri-t-butylphosphine)palladium(0); potassium phosphate / N,N-dimethyl acetamide / 18 h / 80 °C
With
potassium phosphate; bis(tri-t-butylphosphine)palladium(0); potassium tert-butylate; sodium ethanolate; sodium hydride; potassium carbonate; lithium chloride; hydrazine;
In
tetrahydrofuran; ethanol; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
4.1: |Dieckmann Condensation / 5.1: |Krapcho Dealkoxycarbonylation;
DOI:10.1016/j.bmcl.2014.04.087
