Technology Process of 6,8-dimethoxy-1-(2'-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
There total 6 articles about 6,8-dimethoxy-1-(2'-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron tribromide / dichloromethane
2.1: triethylamine / tetrahydrofuran
3.1: palladium diacetate; triphenylphosphine / isopropyl alcohol / 0.5 h / 20 °C / Inert atmosphere
3.2: 16 h / Inert atmosphere; Reflux
4.1: hydrogenchloride; water / diethyl ether
With
hydrogenchloride; water; palladium diacetate; boron tribromide; triethylamine; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; dichloromethane; isopropyl alcohol;
3.1: Suzuki-Miyaura coupling reaction / 3.2: Suzuki-Miyaura coupling reaction;
DOI:10.1007/s00044-010-9356-8
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / tetrahydrofuran
2.1: palladium diacetate; triphenylphosphine / isopropyl alcohol / 0.5 h / 20 °C / Inert atmosphere
2.2: 16 h / Inert atmosphere; Reflux
3.1: hydrogenchloride; water / diethyl ether
With
hydrogenchloride; water; palladium diacetate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; isopropyl alcohol;
2.1: Suzuki-Miyaura coupling reaction / 2.2: Suzuki-Miyaura coupling reaction;
DOI:10.1007/s00044-010-9356-8
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diethyl cyanophosphonate; triethylamine / N,N-dimethyl-formamide
2.1: trichlorophosphate / acetonitrile
3.1: sodium tetrahydroborate / methanol; water
4.1: sodium hydroxide / tetrahydrofuran; dichloromethane
5.1: boron tribromide / dichloromethane
6.1: triethylamine / tetrahydrofuran
7.1: palladium diacetate; triphenylphosphine / isopropyl alcohol / 0.5 h / 20 °C / Inert atmosphere
7.2: 16 h / Inert atmosphere; Reflux
8.1: hydrogenchloride; water / diethyl ether
With
hydrogenchloride; sodium tetrahydroborate; diethyl cyanophosphonate; water; palladium diacetate; boron tribromide; triethylamine; triphenylphosphine; sodium hydroxide; trichlorophosphate;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile;
2.1: Bischler-Napieralski reaction / 7.1: Suzuki-Miyaura coupling reaction / 7.2: Suzuki-Miyaura coupling reaction;
DOI:10.1007/s00044-010-9356-8
