Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate

Base Information

Chemical Name:Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate
CAS No.:118143-77-4
Molecular Formula:C₁₃H₂₁NO₅
Molecular Weight:271.313
Hs Code.:
DSSTox Substance ID:DTXSID201155490

Synonyms:DTXSID201155490;Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate;118143-77-4

Suppliers and Price of Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:271.14197277
Heavy Atom Count:19
Complexity:372

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)C1CCCCN1C(=O)C(=O)OC
Isomeric SMILES:CC(C)(C)OC(=O)[C@@H]1CCCCN1C(=O)C(=O)OC

Technology Process of Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate

There total 2 articles about Methyl (2S)-2-[(1,1-dimethylethoxy)carbonyl]-alpha-oxo-1-piperidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 118143-82-1
(S)-1-{2-[(2R,3R,5S,6S)-2-Hydroxy-3,5-dimethyl-6-((S)-1-phenyl-ethyl)-tetrahydro-pyran-2-yl]-2-oxo-acetyl}-piperidine-2-carboxylic acid tert-butyl ester

: 118143-77-4
(S)-tert-butyl N-methoxalylpipecolate

: 118204-96-9
(3R,5S,6S)-3,5-Dimethyl-6-((S)-1-phenyl-ethyl)-tetrahydro-pyran-2-one

Guidance literature:: With lead(IV) acetate; In methanol;
DOI:10.1021/jo00262a005

Reference yield:

: 118204-95-8
(S)-1-{2-[(2S,3S,5R,6R)-2-Hydroxy-3,5-dimethyl-6-((R)-1-phenyl-ethyl)-tetrahydro-pyran-2-yl]-2-oxo-acetyl}-piperidine-2-carboxylic acid tert-butyl ester

: 118143-77-4
(S)-tert-butyl N-methoxalylpipecolate

: 118204-97-0
(3S,5R,6R)-3,5-Dimethyl-6-((R)-1-phenyl-ethyl)-tetrahydro-pyran-2-one

Guidance literature:: With lead(IV) acetate; In methanol;
DOI:10.1021/jo00262a005

Reference yield:

: 118143-77-4
(S)-tert-butyl N-methoxalylpipecolate

: 118143-81-0,118204-94-7
(S)-1-{2-[2-(4-Hydroxy-1,3-dimethyl-5-phenyl-hexyl)-[1,3]dithian-2-yl]-2-oxo-acetyl}-piperidine-2-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) BuLi, TMEDA / 1.) -20 deg C, 2 h, 2.) -78 deg C

2: HF / acetonitrile

With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen fluoride; In acetonitrile;
DOI:10.1021/jo00262a005