(3-chloro-2-fluorophenyl)methanesulfonyl chloride

Base Information

• Chemical Name: (3-chloro-2-fluorophenyl)methanesulfonyl chloride
• CAS No.: 1314905-61-7
• Molecular Formula: C₇H₅Cl₂FO₂S
• Molecular Weight: 243.086
• Mol file: 1314905-61-7.mol

Synonyms:

Chemical Property of (3-chloro-2-fluorophenyl)methanesulfonyl chloride

Chemical Property:

Purity/Quality:

(3-CHLORO-2-FLUOROPHENYL)METHANESULFONYL CHLORIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-chloro-2-fluorophenyl)methanesulfonyl chloride

There total 1 articles about (3-chloro-2-fluorophenyl)methanesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-chloro-2-fluorobenzyl chloride (876384-47-3) → C7H5Cl2FO2S (1314905-61-7)

Guidance literature:

3-chloro-2-fluorobenzyl chloride; With thiourea; In ethanol; at 96 ℃; for 3h;

With hydrogenchloride; N-chloro-succinimide; In ethanol; water; acetonitrile; at 0 - 20 ℃; for 1.25h;

DOI:10.1021/acs.organomet.7b00309

Reference yield:

2-hydroxy-4 methoxybenzonitrile (39835-11-5) + C7H5Cl2FO2S (1314905-61-7) → 2-cyano-5-methoxyphenyl (3-chloro-2-fluoro-5-(trimethylsilyl)phenyl)methanesulfonate

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 20 °C / Inert atmosphere

2: palladium diacetate; N-acetylglycine; silver carbonate; sodium sulfate / 48 h / 45 - 65 °C / Molecular sieve

With palladium diacetate; sodium sulfate; triethylamine; silver carbonate; N-acetylglycine; In dichloromethane;

DOI:10.1021/acs.organomet.7b00309

upstream raw materials:

3-chloro-2-fluorobenzyl chloride

Refernces