(2R)-N₁-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N₄-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide

Base Information

• Chemical Name: (2R)-N₁-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N₄-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide
• CAS No.: 1228015-90-4
• Molecular Formula: C₃₄H₄₅F₃N₈O₆
• Molecular Weight: 718.777
• Mol file: 1228015-90-4.mol

Synonyms:

Chemical Property of (2R)-N₁-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N₄-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-N₁-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N₄-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide

There total 1 articles about (2R)-N₁-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N₄-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C50H74F3N8O10PolSi → (2R)-N1-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N4-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide (1228015-90-4)

Guidance literature:

With chlorotriisopropylsilane; water; trifluoroacetic acid; for 2h; Inert atmosphere;

DOI:10.1002/ejoc.200901385

Reference yield: 55.0%

(2R)-N1-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N4-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide (1228015-90-4) + BODIPY FL NHS ester → HA-succ(tmd)-Phe-Ahx-Lys(Bodipy-FL)-NH2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200901385

Reference yield: 31.0%

Bodipy-(TMR)-OSu (485397-12-4) + (2R)-N1-[(2S)-1-{6-[(S)-1,6-diamino-1-oxohexan-2-ylamino]-6-oxohexylamino}-1-oxo-3-phenylpropan-2-yl]-N4-hydroxy-2-{4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl}succinamide (1228015-90-4) → HA-succ(tmd)-Phe-Ahx-Lys(Bodipy-TMR)-NH2

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 24h; Inert atmosphere;

DOI:10.1002/ejoc.200901385