[R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide

Base Information

• Chemical Name: [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide
• CAS No.: 1399282-01-9
• Molecular Formula: C₃₂H₃₁F₃N₂O₃S
• Molecular Weight: 580.671
• Mol file: 1399282-01-9.mol

Synonyms:

Chemical Property of [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide

There total 3 articles about [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

trifluoromethane sulfonyl chloride (421-83-0) + (4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine (147700-75-2) → (3aS,8aS)-hexahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-d][1,2,7]thiadiazepine 6,6-dioxide (1399281-99-2) + [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-01-9) + [S(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-07-5)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at -40 - 20 ℃; for 19h;

DOI:10.1002/hlca.201200148

Reference yield: 15.0%

trifluoromethane sulfonyl chloride (421-83-0) + (4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine (147700-75-2) → (3aS,8aS)-hexahydro-2,2-dimethyl-4,4,8,8-tetraphenyl-1,3-dioxolo[4,5-d][1,2,7]thiadiazepine 6,6-dioxide (1399281-99-2) + [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-01-9) + [S(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-07-5) + [S(S)]-N-[{(4S,5S)-5-[({[bis(1-methylethyl)amino]methyl}amino)(diphenyl)methyl]-2,2-di-methyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 - 20 ℃; for 10h;

DOI:10.1002/hlca.201200148

Reference yield: 4.0%

trifluoromethane sulfonyl chloride (421-83-0) + (4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine (147700-75-2) → [R(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-01-9) + [S(S)]-N-[{(4S,5S)-5-[(amino)(diphenyl)methyl]-2,2-dimethyl-1,3-dioxolan-4-yl}(diphenyl)methyl]-1,1,1-trifluoromethanesulfinamide (1399282-07-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -40 - 20 ℃; for 1.5h;

DOI:10.1002/hlca.201200148

upstream raw materials:

trifluoromethane sulfonyl chloride

(4S,5S)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanamine