2-(Isopropylamino)-5-nitrobenzenecarboxylic acid

Base Information

• Chemical Name: 2-(Isopropylamino)-5-nitrobenzenecarboxylic acid
• CAS No.: 1019387-83-7
• Molecular Formula: C₁₀H₁₂N₂O₄
• Molecular Weight: 224.216
• Mol file: 1019387-83-7.mol

Synonyms:

Chemical Property of 2-(Isopropylamino)-5-nitrobenzenecarboxylic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

2-(Isopropylamino)-5-nitrobenzenecarboxylic acid >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(Isopropylamino)-5-nitrobenzenecarboxylic acid

There total 5 articles about 2-(Isopropylamino)-5-nitrobenzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl 2-(isopropylamino)-5-nitrobenzoate (1221791-75-8) → 2-(isopropylamino)-5-nitrobenzoic acid (1019387-83-7)

Guidance literature:

With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 10 - 75 ℃; for 2.5h;

Reference yield:

methyl 2-hydroxy-5-nitrobenzoate (17302-46-4) → 2-(isopropylamino)-5-nitrobenzoic acid (1019387-83-7)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine / dichloromethane / 0.33 h / 0 - 20 °C

2: 1-methyl-pyrrolidin-2-one / 0.08 h / 210 °C / Microwave irradiation

3: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

With water; triethylamine; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

DOI:10.1039/c5ra04714e

Reference yield:

methyl 5-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate (474521-55-6) → 2-(isopropylamino)-5-nitrobenzoic acid (1019387-83-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-methyl-pyrrolidin-2-one / 0.08 h / 210 °C / Microwave irradiation

2: sodium hydroxide; water / methanol; tetrahydrofuran / 2 h / 60 °C

With water; sodium hydroxide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol;

DOI:10.1039/c5ra04714e

upstream raw materials:

methyl 2-hydroxy-5-nitrobenzoate

methyl 5-nitro-2-{[(trifluoromethyl)sulfonyl]oxy}benzoate

methyl 2-(isopropylamino)-5-nitrobenzoate

methyl 2-fluoro-5-nitro-benzoate

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND". Paragraph 1104. . Retrieved 2016/03/18.