(2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane

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Chemical Name:(2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane
CAS No.:129783-78-4
Molecular Formula:C₁₄H₁₇NO
Molecular Weight:215.295
Hs Code.:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane

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Technology Process of (2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane

There total 2 articles about (2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 2622-05-1
allylmagnesium bromide

: 129679-96-5
(4R,5S)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole p-toluenesulfonate

: 129783-78-4
(2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane

Guidance literature:: In tetrahydrofuran; 1) 1 h, 0 deg C, 2) reflux, 3 h; reaction also in presence of Li₂CuCl₄ and under Schlosser conditions;
DOI:10.1021/jo00312a033

Reference yield:

: 129783-77-3
(4R,5S)-2-phenyl-4-(hydroxymethyl)-5-methyl-4,5-dihydrooxazole

: 129783-78-4
(2R,4R,5S)-2-phenyl-2-(2-propen-1-yl)-5-methyl-1-oxa-3-aza<3.1.0>bicyclohexane

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / pyridine / 24 h / Ambient temperature

2: 70 percent / tetrahydrofuran / 1) 1 h, 0 deg C, 2) reflux, 3 h; reaction also in presence of Li₂CuCl₄ and under Schlosser conditions

With pyridine; In tetrahydrofuran;
DOI:10.1021/jo00312a033