Technology Process of (1S,4aS,5S,6S,8aS)-6-Benzyloxy-3,3-dimethoxy-5,8a-dimethyl-decahydro-naphthalene-1-carboxylic acid methyl ester
There total 7 articles about (1S,4aS,5S,6S,8aS)-6-Benzyloxy-3,3-dimethoxy-5,8a-dimethyl-decahydro-naphthalene-1-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
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104996-08-9,104996-09-0
(4aS,7R,8R,8aR)-7-Benzyloxy-4a,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydro-naphthalen-2-ol
- Guidance literature:
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Multi-step reaction with 5 steps
1: MnO2 / CH2Cl2 / 18 h / Ambient temperature
2: 74 percent / NH4Cl / dimethylformamide; H2O / 3 h / 70 - 80 °C
3: 83 percent / p-TsOH / methanol / 24 h / Ambient temperature
4: KOH / bis-(2-hydroxy-ethyl) ether / 36 h / 200 °C
5: diethyl ether
With
manganese(IV) oxide; potassium hydroxide; ammonium chloride; toluene-4-sulfonic acid;
In
methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; diethylene glycol;
DOI:10.1021/jo00374a016
- Guidance literature:
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Multi-step reaction with 7 steps
1: 30percent hydrogen peroxide, 6 N aq. sodium hydroxide / methanol / 3 h / Ambient temperature
2: 95percent hydrazine, glacial acetic acid / methanol / 2 h / Heating
3: MnO2 / CH2Cl2 / 18 h / Ambient temperature
4: 74 percent / NH4Cl / dimethylformamide; H2O / 3 h / 70 - 80 °C
5: 83 percent / p-TsOH / methanol / 24 h / Ambient temperature
6: KOH / bis-(2-hydroxy-ethyl) ether / 36 h / 200 °C
7: diethyl ether
With
manganese(IV) oxide; potassium hydroxide; sodium hydroxide; dihydrogen peroxide; ammonium chloride; toluene-4-sulfonic acid; hydrazine hydrate; acetic acid;
In
methanol; diethyl ether; dichloromethane; water; N,N-dimethyl-formamide; diethylene glycol;
DOI:10.1021/jo00374a016
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 74 percent / NH4Cl / dimethylformamide; H2O / 3 h / 70 - 80 °C
2: 83 percent / p-TsOH / methanol / 24 h / Ambient temperature
3: KOH / bis-(2-hydroxy-ethyl) ether / 36 h / 200 °C
4: diethyl ether
With
potassium hydroxide; ammonium chloride; toluene-4-sulfonic acid;
In
methanol; diethyl ether; water; N,N-dimethyl-formamide; diethylene glycol;
DOI:10.1021/jo00374a016
