4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Base Information

Chemical Name:4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester
CAS No.:143539-74-6
Molecular Formula:C₄₂H₅₆FIO₄
Molecular Weight:770.807
Hs Code.:

4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

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Chemical Property of 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Chemical Property:

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Technology Process of 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

There total 10 articles about 4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80-97-7
Cholestanol

: 143539-74-6
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 10 steps

1: 96 percent / Ph₃P, DIAD

2: 1.) PhICl₂, 2.) KOH / 1.) irradiation

5: HF

6: KOH

7: 97 percent

8: 1.) BuLi / 1.) -78 deg C

9: 96 percent / HF

10: 10percent pyridine, DMAP / benzene / Heating

With pyridine; dmap; potassium hydroxide; n-butyllithium; di-isopropyl azodicarboxylate; (Dichloroiodo)benzene; hydrogen fluoride; triphenylphosphine; In benzene;
DOI:10.1016/S0040-4039(00)74674-0

Reference yield:

: 37772-03-5
Cholest-Δ⁹⁽¹¹⁾-3-en-3α-yl acetate

: 143539-74-6
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 7 steps

2: HF

3: KOH

4: 97 percent

5: 1.) BuLi / 1.) -78 deg C

6: 96 percent / HF

7: 10percent pyridine, DMAP / benzene / Heating

With pyridine; dmap; potassium hydroxide; n-butyllithium; hydrogen fluoride; In benzene;
DOI:10.1016/S0040-4039(00)74674-0

Reference yield:

: 37772-32-0
cholest-9(11)-en-3α-ol

: 143539-74-6
4'-Iodo-biphenyl-3-carboxylic acid (3R,5S,8S,9R,10S,11S,13R,14S,17R)-11-acetoxy-17-((R)-1,5-dimethyl-hexyl)-9-fluoro-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-3-yl ester

Guidance literature:: Multi-step reaction with 8 steps

3: HF

4: KOH

5: 97 percent

6: 1.) BuLi / 1.) -78 deg C

7: 96 percent / HF

8: 10percent pyridine, DMAP / benzene / Heating

With pyridine; dmap; potassium hydroxide; n-butyllithium; hydrogen fluoride; In benzene;
DOI:10.1016/S0040-4039(00)74674-0