2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-

Base Information

Chemical Name:2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-
CAS No.:138712-65-9
Molecular Formula:C16H13NO2
Molecular Weight:251.285
Hs Code.:
DSSTox Substance ID:DTXSID80459875
Wikidata:Q82283750

Synonyms:138712-65-9;2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-;DTXSID80459875

Suppliers and Price of 2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-

Chemical Property:

XLogP3:2.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:251.094628657
Heavy Atom Count:19
Complexity:382

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=C(C(=O)NC3=CC=CC=C32)CO

Technology Process of 2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl-

There total 2 articles about 2(1H)-Quinolinone, 3-(hydroxymethyl)-4-phenyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 102028-51-3
2-oxo-4-phenyl-1,2-dihydroquinoline-3-carboxylic acid ethyl ester

: 138712-65-9
3-hydroxymethyl-4-phenyl-2(1H)-quinolinone

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h; Ambient temperature;
DOI:10.1002/jhet.5570280727

Reference yield:

: 615-43-0
2-iodophenylamine

: 138712-65-9
3-hydroxymethyl-4-phenyl-2(1H)-quinolinone

Guidance literature:: Multi-step reaction with 2 steps

1.1: 95 percent / K₂CO₃ / acetone / 3 h / 20 °C

2.1: pyridine; n-Bu₄NCl; Pd(OAc)2 / dimethylformamide / 12 h / 100 °C / 760 Torr

2.2: NaOH / ethanol / 0.5 h / 20 °C

With pyridine; palladium diacetate; tetrabutyl-ammonium chloride; potassium carbonate; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/jo049149+