Technology Process of 5,7-diamino-N5-<2-(4-fluorophenyl)ethyl>-6-methyl-3-(β-D-ribofuranosyl)imidazo<4,5-b>pyridine
There total 7 articles about 5,7-diamino-N5-<2-(4-fluorophenyl)ethyl>-6-methyl-3-(β-D-ribofuranosyl)imidazo<4,5-b>pyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 44 percent / borane-pyridine complex, acetic acid / petroleum ether / 2 h / Ambient temperature
2: 83 percent / triethylamine / CH2Cl2 / Ambient temperature
3: 41 percent / phosphoryl chloride / acetonitrile / 48 h
4: ammonia / methanol
5: 42 percent / sodium hydride / dioxane / 2 h / Heating
6: 56 percent / H2, 1 N hydrochloric acid / palladium hydroxide / aq. ethanol / 6 h / 2585.7 Torr / Ambient temperature
7: 1.) 90percent trifluoroacetic acid 2.) propylene oxide / 1.) 0 to 5 deg C, 1 h 2.) 30 min
With
hydrogenchloride; borane pyridine; ammonia; hydrogen; sodium hydride; acetic acid; triethylamine; trifluoroacetic acid; methyloxirane; trichlorophosphate;
palladium dihydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile; Petroleum ether;
DOI:10.1139/v92-166
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 83 percent / triethylamine / CH2Cl2 / Ambient temperature
2: 41 percent / phosphoryl chloride / acetonitrile / 48 h
3: ammonia / methanol
4: 42 percent / sodium hydride / dioxane / 2 h / Heating
5: 56 percent / H2, 1 N hydrochloric acid / palladium hydroxide / aq. ethanol / 6 h / 2585.7 Torr / Ambient temperature
6: 1.) 90percent trifluoroacetic acid 2.) propylene oxide / 1.) 0 to 5 deg C, 1 h 2.) 30 min
With
hydrogenchloride; ammonia; hydrogen; sodium hydride; triethylamine; trifluoroacetic acid; methyloxirane; trichlorophosphate;
palladium dihydroxide;
In
1,4-dioxane; methanol; ethanol; dichloromethane; acetonitrile;
DOI:10.1139/v92-166
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 41 percent / phosphoryl chloride / acetonitrile / 48 h
2: ammonia / methanol
3: 42 percent / sodium hydride / dioxane / 2 h / Heating
4: 56 percent / H2, 1 N hydrochloric acid / palladium hydroxide / aq. ethanol / 6 h / 2585.7 Torr / Ambient temperature
5: 1.) 90percent trifluoroacetic acid 2.) propylene oxide / 1.) 0 to 5 deg C, 1 h 2.) 30 min
With
hydrogenchloride; ammonia; hydrogen; sodium hydride; trifluoroacetic acid; methyloxirane; trichlorophosphate;
palladium dihydroxide;
In
1,4-dioxane; methanol; ethanol; acetonitrile;
DOI:10.1139/v92-166
