G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime

Base Information

• Chemical Name: G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime
• CAS No.: 1292807-46-5
• Molecular Formula: C₆₆H₉₀N₁₂O₁₂S₂
• Molecular Weight: 1307.65
• Mol file: 1292807-46-5.mol

Synonyms:

Chemical Property of G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime

There total 1 articles about G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Fmoc-D-3-(2-naphthyl)alaninal (1224977-11-0) + N-(fluoren-9-ylmethoxycarbonyl)glycine (29022-11-5) + Fmoc-D-Tyr(O-tBu)-OH (118488-18-9,204384-67-8) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime (1292807-46-5)

Guidance literature:

Fmoc-D-3-(2-naphthyl)alaninal; With C₁₉H₁₅ClNOPol; acetic acid; trimethyl orthoformate; In 1,2-dichloro-ethane; at 60 ℃; for 2h; Inert atmosphere; solid phase reaction;

With piperidine; In N,N-dimethyl-formamide; Inert atmosphere; solid phase reaction;

N-(fluoren-9-ylmethoxycarbonyl)glycine; Fmoc-D-Tyr(O-tBu)-OH; Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; Further stages;

DOI:10.1021/ml200047e

Reference yield:

G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime (1292807-46-5) → cyclo[-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-ψ[C(=NOH)-NH]-Gly-]

Guidance literature:

G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime; With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

With triethylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ml200047e

Reference yield:

G-Gly-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-aldoxime (1292807-46-5) → cyclo[-D-Tyr(t-Bu)-Arg(Pbf)-Arg(Pbf)-D-Nal-ψ[C(=NH)-NH]-Gly-]

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-chloro-succinimide / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere

2.1: hydrogen; acetic acid / methanol; water / 2 h / 20 °C

With N-chloro-succinimide; hydrogen; acetic acid; In methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/ml200047e

upstream raw materials:

Fmoc-D-3-(2-naphthyl)alaninal

N-(fluoren-9-ylmethoxycarbonyl)glycine

Fmoc-D-Tyr(O-tBu)-OH

Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine

Downstream raw materials:

cyclo[-D-Tyr-Arg-Arg-D-Nal-ψ[C(=NH)-NH]-Gly-]