Technology Process of 5-amino-2-bromo-4-methylbenzonitrile
There total 1 articles about 5-amino-2-bromo-4-methylbenzonitrile which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
N-Bromosuccinimide;
In
N,N-dimethyl-formamide;
at 20 ℃;
Cooling with ice;
DOI:10.1021/jm401986p
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere
1.2: 20 °C
2.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C
3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 120 °C / Microwave irradiation
With
tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; boron trifluoride diethyl etherate; caesium carbonate; toluene-4-sulfonic acid;
In
1,4-dioxane; dichloromethane; chloroform; water;
3.1: |Suzuki Coupling;
DOI:10.1021/jm401986p
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: boron trifluoride diethyl etherate; tert.-butylnitrite / dichloromethane / -78 - 20 °C / Inert atmosphere
1.2: 20 °C
2.1: toluene-4-sulfonic acid / chloroform / 20 - 50 °C
3.1: caesium carbonate; tetrakis(triphenylphosphine) palladium(0) / water; 1,4-dioxane / 120 °C / Microwave irradiation
4.1: hydrogenchloride / methanol; 1,4-dioxane / 20 °C
With
hydrogenchloride; tetrakis(triphenylphosphine) palladium(0); tert.-butylnitrite; boron trifluoride diethyl etherate; caesium carbonate; toluene-4-sulfonic acid;
In
1,4-dioxane; methanol; dichloromethane; chloroform; water;
3.1: |Suzuki Coupling;
DOI:10.1021/jm401986p
