N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide
CAS No.:1449423-87-3
Molecular Formula:C₃₃H₃₁N₉O₃
Molecular Weight:601.668
Hs Code.:

N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Synonyms:

Suppliers and Price of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

There total 9 articles about N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1449424-02-5
12-(3-aminophenyl)-2-((2-methoxy-4-(4-methylpiperazin-1-yl)phenyl)amino)benzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidin-5(12H)-one

: 814-68-6,25189-84-8
acryloyl chloride

: 1449423-87-3
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;
DOI:10.1002/anie.201302313

Reference yield:

: 51940-64-8
ethyl 2,4-dichloropyrimidine-5-carboxylate

: 1449423-87-3
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

2: sodium hydroxide; water / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4: dichloromethane / 24 h / 20 °C

5: potassium carbonate / tert-butyl alcohol / 24 h / 110 °C / Sealed tube

6: trifluoroacetic acid / dichloromethane / 20 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1002/anie.201302313

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1449423-87-3
N-(3-(2-((2-methoxy-4-(4-methyl-1-piperazinyl)phenyl)amino)-5-oxobenzo[4,5]imidazo[1,2-a]pyrimido[4,5-d]pyrimidine-12(5H)-yl)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / acetonitrile / 2 h / 80 °C

2: sodium hydroxide; water / tetrahydrofuran / 4 h / 50 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.5 h / 20 °C

4: dichloromethane / 24 h / 20 °C

5: potassium carbonate / tert-butyl alcohol / 24 h / 110 °C / Sealed tube

6: trifluoroacetic acid / dichloromethane / 20 °C

7: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 0 - 20 °C

With water; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; dichloromethane; acetonitrile; tert-butyl alcohol;
DOI:10.1002/anie.201302313