propargyl-PEG3-Acid

Base Information

• Chemical Name: propargyl-PEG3-Acid
• CAS No.: 1347760-82-0
• Molecular Formula: C₁₀H₁₆O₅
• Molecular Weight: 216.234
• Mol file: 1347760-82-0.mol

Synonyms:

Chemical Property of propargyl-PEG3-Acid

Chemical Property:

• Storage Temp.: -20°C
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

98%,99%, ^*data from raw suppliers

Propargyl-PEG3-Acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Propargyl-PEG3-acid is a reagent with an alkyne group and a carboxylic acid. The terminal carboxylic acid can form amide bond with primary amines (activation is needed). The alkyne can form triazole linkage with azide containing molecules via copper catalyzed reactions.
• Uses: Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC? molecules) for targeted protein degradation.

Technology Process of propargyl-PEG3-Acid

There total 1 articles about propargyl-PEG3-Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C14H24O5 → 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoic acid (1347760-82-0,1421676-62-1)

Guidance literature:

With trifluoroacetic acid; In water; at 20 ℃; for 72h;

DOI:10.1039/d1tb02144c