C₂₂H₂₀F₃N₅O

Base Information

• Chemical Name: C₂₂H₂₀F₃N₅O
• CAS No.: 1312813-32-3
• Molecular Formula: C₂₂H₂₀F₃N₅O
• Molecular Weight: 427.429
• Mol file: 1312813-32-3.mol

Synonyms:

Chemical Property of C₂₂H₂₀F₃N₅O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₀F₃N₅O

There total 7 articles about C₂₂H₂₀F₃N₅O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate (362703-35-3) → C22H20F3N5O (1312813-32-3)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium tris(acetoxy)borohydride / ethanol / 20 °C

2: pyridine; dmap / dichloromethane / 20 °C

3: sodium methylate / methanol / 60 °C

4: water; acetonitrile / 80 °C

5: ammonium acetate / ethanol

6: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate / 1,4-dioxane / 140 °C / Microwave irradiation

7: trifluoroacetic acid / 20 °C

With pyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate; ammonium acetate; sodium methylate; sodium tris(acetoxy)borohydride; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile; 3: Dieckmann reaction / 5: Paal-Knorr condensation / 6: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.04.016

Reference yield:

C23H36N2O7 → C22H20F3N5O (1312813-32-3)

Guidance literature:

Multi-step reaction with 6 steps

1: pyridine; dmap / dichloromethane / 20 °C

2: sodium methylate / methanol / 60 °C

3: water; acetonitrile / 80 °C

4: ammonium acetate / ethanol

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate / 1,4-dioxane / 140 °C / Microwave irradiation

6: trifluoroacetic acid / 20 °C

With pyridine; dmap; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate; ammonium acetate; sodium methylate; trifluoroacetic acid; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetonitrile; 2: Dieckmann reaction / 4: Paal-Knorr condensation / 5: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.04.016

Reference yield:

C24H34N2O7 → C22H20F3N5O (1312813-32-3)

Guidance literature:

Multi-step reaction with 3 steps

1: ammonium acetate / ethanol

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate / 1,4-dioxane / 140 °C / Microwave irradiation

3: trifluoroacetic acid / 20 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate tribasic heptahydrate; ammonium acetate; trifluoroacetic acid; In 1,4-dioxane; ethanol; 1: Paal-Knorr condensation / 2: Suzuki coupling;

DOI:10.1016/j.bmcl.2011.04.016

upstream raw materials:

1-tert-butyl 4-methyl 4-(aminomethyl)piperidine-1,4-dicarboxylate