3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride

Base Information

• Chemical Name: 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride
• CAS No.: 1610999-12-6
• Molecular Formula: C₂₄H₃₅N₃O*ClH
• Molecular Weight: 418.022
• Mol file: 1610999-12-6.mol

Synonyms:

Chemical Property of 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride

There total 6 articles about 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-[3-(benzyloxy)phenyl]-6-(4-phenylpiperazin-1-yl)hexanamide (1610998-68-9) → 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride (1610999-12-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

2: acetic acid; sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C

3: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

4: hydrogenchloride / methanol

With hydrogenchloride; lithium aluminium tetrahydride; boron trichloride; sodium cyanoborohydride; acetic acid; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

N-[3-(benzyloxy)phenyl]-6-bromohexanamide (1610998-51-0) → 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride (1610999-12-6)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / N,N-dimethyl-formamide / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / Cooling with ice; Inert atmosphere; Reflux

3: acetic acid; sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C

4: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

5: hydrogenchloride / methanol

With hydrogenchloride; lithium aluminium tetrahydride; boron trichloride; sodium cyanoborohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2014.04.034

Reference yield:

3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline (1610998-79-2) → 3-{ethyl[6-(4-phenylpiperazin-1-yl)hexyl]amino}phenol hydrochloride (1610999-12-6)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid; sodium cyanoborohydride / methanol / 16 h / 0 - 20 °C

2: boron trichloride / dichloromethane / 1 h / 0 - 20 °C

3: hydrogenchloride / methanol

With hydrogenchloride; boron trichloride; sodium cyanoborohydride; acetic acid; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2014.04.034

upstream raw materials:

N-[3-(benzyloxy)phenyl]-6-bromohexanamide

N-[3-(benzyloxy)phenyl]-6-(4-phenylpiperazin-1-yl)hexanamide

3-(benzyloxy)-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline

3-(benzyloxy)-N-ethyl-N-[6-(4-phenylpiperazin-1-yl)hexyl]aniline