(2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid

Base Information

• Chemical Name: (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid
• CAS No.: 1351534-24-1
• Molecular Formula: C₂₆H₁₉ClF₃N₃O₇
• Molecular Weight: 577.901
• Mol file: 1351534-24-1.mol

Synonyms:

Chemical Property of (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid

There total 11 articles about (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-[6-methoxybenzisoxazol-3-yl]-6-trifluoromethoxybenzimidazole-2-one (877681-17-9) + (2R)-[5-(bromomethyl)-2-chlorophenoxy]propanoic acid methyl ester (1351534-07-0) → (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-24-1)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm201061j

Reference yield:

1-[6-chlorobenzisoxazol-3-yl]-6-trifluoromethoxybenzimidazole-2-one (877681-16-8) → (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-24-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol; N,N-dimethyl-formamide / 80 - 110 °C / Inert atmosphere

1.2: 2 h / pH 6 / Cooling with ice; Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With caesium carbonate; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm201061j

Reference yield:

2-amino-4-trifluoromethoxy-N-acetylaniline (1351534-05-8) → (2R)-2-[2-chloro-5-[[3-(6-methoxybenzisoxazol-3-yl)-2-oxo-5-trifluoromethoxybenzimidazol-1-yl]methyl]phenoxy]propanoic acid (1351534-24-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: sodium hydroxide / methanol; water / 70 °C

2.1: tetrahydrofuran / 70 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 20 °C

4.1: caesium carbonate / N,N-dimethyl-formamide / 150 °C

5.1: methanol; N,N-dimethyl-formamide / 80 - 110 °C / Inert atmosphere

5.2: 2 h / pH 6 / Cooling with ice; Inert atmosphere

6.1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

With sodium hydride; caesium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm201061j

upstream raw materials:

1-[6-chlorobenzisoxazol-3-yl]-6-trifluoromethoxybenzimidazole-2-one

1-[6-methoxybenzisoxazol-3-yl]-6-trifluoromethoxybenzimidazole-2-one

(2R)-[5-(bromomethyl)-2-chlorophenoxy]propanoic acid methyl ester

(2R)-(2-chloro-5-methylphenoxy)propanoic acid methyl ester