Technology Process of (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate-
There total 7 articles about (S)-2-(dimethylamino)-1-phenylethyl 6,6-dimethyl-3-(3,3,3-trifluoro-2,2-dimethylpropanamido)-4,6-dihydropyrrolo[3,4c]pyrazole-5(1H)-carboxylate- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium tert-butylate / toluene / 0 - 5 °C
2.1: hydrazine hydrate; acetic acid / ethanol / 12 h / Reflux
3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 4.5 h / 0 - 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C
4.2: 15 h / 0 - 20 °C
5.1: hydrogenchloride / 1,4-dioxane; water; ethyl acetate / 14 h / 20 °C
6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.33 h / -78 °C
7.1: potassium carbonate / 1,2-dimethoxyethane / 80 °C
8.1: triethylamine / methanol / 20 °C
With
hydrogenchloride; oxalyl dichloride; potassium tert-butylate; potassium carbonate; hydrazine hydrate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;
In
tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; dichloromethane; water; ethyl acetate; toluene;
DOI:10.1021/jm300204j
- Guidance literature:
-
Multi-step reaction with 3 steps
1: formic acid; water / 19 h / 20 - 95 °C
2: potassium carbonate / 1,2-dimethoxyethane / 80 °C
3: triethylamine / methanol / 20 °C
With
potassium carbonate; triethylamine;
In
methanol; 1,2-dimethoxyethane; formic acid; water;
DOI:10.1021/jm300204j