(S)-7-phenylazepan-2-one

Base Information

• Chemical Name: (S)-7-phenylazepan-2-one
• CAS No.: 1429410-85-4
• Molecular Formula: C₁₂H₁₅NO
• Molecular Weight: 189.257
• Mol file: 1429410-85-4.mol

Synonyms:

Chemical Property of (S)-7-phenylazepan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-7-phenylazepan-2-one

There total 9 articles about (S)-7-phenylazepan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

(S)-trans-2-phenylcyclohexanone oxime → (S)-7-phenylazepan-2-one (1429410-85-4)

Guidance literature:

(S)-trans-2-phenylcyclohexanone oxime; With pyridine; at 0 ℃; Inert atmosphere; Schlenk technique;

With p-toluenesulfonyl chloride; at 0 ℃; for 8h;

DOI:10.1002/anie.201300621

Reference yield:

C18H29NO3S → (S)-7-phenylazepan-2-one (1429410-85-4)

Guidance literature:

C₁₈H₂₉NO₃S; With hydrogenchloride; In methanol; diethyl ether; at 0 - 20 ℃;

With sodium methylate; In methanol; diethyl ether; at 0 - 20 ℃;

DOI:10.1021/jo400164y

Reference yield:

1-tri(n-butyl)stannyloxy-1-cyclohexene (17851-97-7) → (S)-7-phenylazepan-2-one (1429410-85-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: (R)-N-isopropyl-2-(dicyclohexylphosphino)-2'-(3-aminophenoxy)-1,1'-binaphthyl; palladium diacetate; sodium acetate / diethyl ether / 0.17 h / 25 °C / Glovebox; Inert atmosphere

1.2: 6 h / 25 °C / Glovebox; Inert atmosphere

2.1: hydroxylamine hydrochloride; potassium carbonate / methanol / 0.5 h / 20 °C

3.1: pyridine / 0 °C / Inert atmosphere; Schlenk technique

3.2: 8 h / 0 °C

With pyridine; (R)-N-isopropyl-2-(dicyclohexylphosphino)-2'-(3-aminophenoxy)-1,1'-binaphthyl; hydroxylamine hydrochloride; sodium acetate; palladium diacetate; potassium carbonate; In methanol; diethyl ether;

DOI:10.1002/anie.201300621

upstream raw materials:

ethyl 6-oxo-6-phenylhexanoate

5-benzoylvaleric acid

bromobenzene

chlorobenzene