2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole

Base Information

• Chemical Name: 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole
• CAS No.: 1234802-04-0
• Molecular Formula: C₂₃H₂₂N₂O₃
• Molecular Weight: 374.439
• Mol file: 1234802-04-0.mol

Synonyms:

Chemical Property of 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole

There total 4 articles about 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N1-benzyl-N1-(3,4,5-trimethoxybenzyl)benzene-1,2-diamine → 1-benzyl-2-(3,4,5-trimethoxyphenyl)-benzimidazole + 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole (1234802-04-0)

Guidance literature:

With iodobenzene; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 4h; Overall yield = 91 %; Overall yield = 54 mg;

DOI:10.1039/c8cc09100e

Reference yield:

C23H24N2O5 → 1-benzyl-2-(3,4,5-trimethoxyphenyl)-benzimidazole + 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole (1234802-04-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; ammonium chloride / water; ethanol / 90 °C / Sealed tube

2: iodobenzene; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With iodobenzene; iron; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water;

DOI:10.1039/c8cc09100e

Reference yield:

ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1-benzyl-2-(3,4,5-trimethoxyphenyl)-benzimidazole + 2-phenyl-1-(3,4,5-trimethoxybenzyl)benzo[d]imidazole (1234802-04-0)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dimethyl sulfoxide / 24 h / 110 °C

2: iron; ammonium chloride / water; ethanol / 90 °C / Sealed tube

3: iodobenzene; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 20 °C

With iodobenzene; iron; potassium carbonate; ammonium chloride; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane; water; dimethyl sulfoxide;

DOI:10.1039/c8cc09100e

upstream raw materials:

N-benzyl-1-(3,4,5-trimethoxyphenyl)methanamine

ortho-nitrofluorobenzene