Technology Process of (S)-N-Boc-(1,4-benzodioxan-2-carbonyl)piperazine
There total 5 articles about (S)-N-Boc-(1,4-benzodioxan-2-carbonyl)piperazine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)‐1,4‐benzodioxane‐2‐carboxylic acid;
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; dichloromethane;
at 0 ℃;
for 0.166667h;
1-t-Butoxycarbonylpiperazine;
In
tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.10.018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: whole cells of Arthrobacter sp. ABL MTCC No. 5125 lipase / aq. phosphate buffer; di-isopropyl ether / 2 h / 25 °C / pH 7.1
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; aq. phosphate buffer; dichloromethane; di-isopropyl ether;
DOI:10.1016/j.tetasy.2012.10.018
- Guidance literature:
-
Multi-step reaction with 2 steps
1: whole cells of Arthrobacter sp. ABL MTCC No. 5125 lipase / aq. phosphate buffer; butan-1-ol / 4 h / 25 °C / pH 7.1
2: triethylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / tetrahydrofuran; dichloromethane / 0.17 h / 0 °C
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine;
In
tetrahydrofuran; aq. phosphate buffer; dichloromethane; butan-1-ol;
DOI:10.1016/j.tetasy.2012.10.018
